
As you can see the areas most likely to be hit by major hurricanes are the southern half of the peninsula and the western half of the panhandle. Very few major hurricanes have hit elsewhere in the state. Of course, regardless of that, the entire state is susceptible.
The majority of the major hurricane strikes occurred during the month of September, followed by October and then August. August and first half of September tends to see the major hurricanes hit from the east. Last half of September into October tends to see the major hurricanes hit from the Gulf of Mexico and the Caribbean. Of course, there are exceptions.
Here is the same data divided by different time periods...
1851-1900:

1901-1950:

1951-2004:

*Please note that data from earlier time periods (although official) may not be totally accurate due to the lack of solid observations before aircraft reconaissance, satellite, radar, etc. became available.
*EDIT: TITLE TO REFLECT CURRENT INFORMATION*